Bird Flu Monitor > Another "big" H5N1 science paper

http://scienceblogs.com/effectmeasure [Effect Measure] The constructed viruses had either a bird H5 or an H5 from a virus isolated from a human together with the N1 from one of the H5N1s and six internal genes from PR8/H1N1, a common laboratory strain. Thus they were not testing H5N1 viral mutants isolated from birds and humans against human and bird cells, but laboratory constructed H5N1s unlike any found in nature.

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http://scienceblogs.com [Scienceblogs.com] Effect Measure: In the study reported in PLoS Medicine, three different ca viruses were prepared by taking the H5 and N1 genetic segments of human H5N1 isolates from 1997, 2004 and 2005 (clades 3, 1 and 2, respectively) and combining them with the other 6 genetic segments coding for the internal proteins of A/Ann Arbor/60. The H5 segment was modified to eliminate the extreme virulence of the virus for chicken cells by clipping out the extra basic amino acids at the cleavage site of H5.

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