Bird Flu Monitor > Antigenically distinct MF59-adjuvanted vaccine to boost immunity ...

[Vietnam RSS News Feed by Intellasia.Net] All primed subjects had received two doses of either MF59-adjuvanted or nonadjuvanted (plain) A/duck/Singapore/97 (H5N3) vaccine containing 7.5 to 30 µg of hemagglutinin in studies conducted between 1999 and 2001.2,3,4 Some subjects had also received a booster dose 16 months after primary immunisation.3 Antibody responses were detected with the use of neutralising and hemagglutination-inhibition assays performed at the UK Health Protection Agency, with homologous clade 1 NIBRG-14 and heterologous clade 2.2 NIBRG-23 vaccine reference strains and by hemagglutination-inhibition assay at the Centres for Disease Control and Prevention with wild-type A/Vietnam/1194/2005 (clade 1), A/Indonesia/5/2005 (clade 2.1), A/Anhui/1/2005 (clade 2.3), and A/Turkey/15/2006 (clade 2.2) viruses.