Bird Flu Monitor > H5N1 influenza has many mutations - The Bird Flu Report
[The Bird Flu Report] To investigate the evolution of avian H5N1 influenza viruses, we undertook a high-resolution analysis of the reassortment of internal genes and evolution of the HA of 651 avian H5N1 viruses from 2000-2008. Our analysis suggested: (i) all current H5N1 genotypes were derived from a single, clearly defined sequence of initial reassortment events;
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[gurumia.com] Satellite Technology Targets Disease Hotspots for Avian Influenza ...: Habitats used as stopover sites and breeding grounds within the Central Asian Flyway will also be identified and ultimately will promote the need to protect these key areas for conservation purposes. The project’s goal is to help clarify whether wild birds could provide researchers with a link between avian influenza outbreaks and the locations of migratory wild birds.
[MEDICAL] PDF: Characterization of Avian H3N3 and H1N1 Influenza A Viruses ...: The basis for species specificity of influenza viruses appears to be polygenic (27, 53, 58, 63, 65, 66, 68), but the HA is hypothesized to be a major factor because of its role as the receptorbinding protein (29, 68). Avian influenza viruses bind preferentially to sialyloligosaccharides with an ”2,3 linkage of N-acetylneuraminic acid to galactose (NAc”2,3Gal), whereas human influenza viruses prefer NAc”2,6Gal receptors, consistent with the fact that NAc”2,3Gal is the major receptor found on duck intestinal cells and that human tracheal epithelial cells express predominantly NAc”2,6Gal molecules (8, 9, 16-18, 36, 49, 50, 68).
[LABVIRUS.COM] Reassortment between avian H5N1 and human H3N2 influenza viruses ...: To evaluate the pathogenic potential of reassortant viruses between currently cocirculating avian H5N1 and human H3N2 influenza viruses, we generated all the 254 combinations of reassortant viruses between A/chicken/South Kalimantan/UT6028/06 (SK06, H5N1) and A/Tokyo/Ut-Sk-1/07 (Tok07, H3N2) influenza viruses by reverse genetics. We found that the presence of Tok07 PB2 protein in the ribonucleoprotein (RNP) complex allowed efficient viral RNA transcription in a minigenome assay and that RNP activity played an essential role in the viability and replicative ability of the reassortant viruses.
[Science JournalFeeds] Reassortment between avian H5N1 and human H3N2 influenza viruses ...: The spread of avian H5N1 influenza viruses around the globe has become a worldwide public health concern. To evaluate the…
[Bioinformatics - Advance Access] A quantitative genotype algorithm reflecting H5N1 Avian influenza ...: Motivation: Computational genotyping analyses are critical for characterizing molecular evolutionary footprints, thus providing important information for designing the strategies of influenza prevention and control. Most of the current methods that are available are based on multiple sequence alignment and phylogenetic tree construction, which are time consuming and limited by the number of taxa.
[H3N2VIRUS.US] Reassortment between avian H5N1 and human H3N2 influenza viruses ”¦: When the pathogenicity of 75 reassortant H5 viruses was tested in mice, 22 were more pathogenic than the parental SK06 virus , and three were extremely virulent. Strikingly, all 22 of these viruses obtained their PB2 segment from Tok07 …
[Not Another CONspiracy] Get Ready for Bird Flu Pandemic: The researchers say surveillance of viral populations is critical to monitor the potential emergence of highly pathogenic viral variants due to reassortment of avian and human influenza viruses. Their results, including identification of the PB2 segment as a key to enhanced virulence, offer information likely to be useful in the event of a pandemic caused by a hybrid avian-human influenza strain.
[free programming ebooks] CHARACTERIZATION OF AVIAN H3N3 AND H1N1 INFLUENZA A VIRUSES ...: The foundation for species specificity of contagion viruses appears to be polygenic (27, 53, 58, 63, 65, 66, 68), but the HA is hypothesized to be a field bourgeois because of its persona as the receptorbinding accelerator (29, 68). Avian contagion viruses bond preferentially to sialyloligosaccharides with an “2,3 inheritance of N-acetylneuraminic Elvis to saccharose (NAc”2,3Gal), whereas manlike contagion viruses favour NAc”2,6Gal receptors, conformable with the fact that NAc”2,3Gal is the field organ institute on score viscus cells and that manlike tracheal epithelial cells impart predominantly NAc”2,6Gal molecules (8, 9, 16-18, 36, 49, 50, 68).
[Monotreme's Blog] NS from H5N1 + H7N1 = Trouble « Monotreme's Blog: surprise, a hybrid strain with the NS genomic segment from H5N1 and the other 7 genomic segments from H7N1, was able to immediately replicate in human cells, without any adaptation. Further, the NS exchange transformed a normally benign H7N1 virus into a lethal strain.
[Health News] Bird flu: Threat persists in five countries: WASHINGTON - Genetic interactions between avian flu virus and human seasonal flu viruses can potentially create hybrid strains, combining the virulence of bird flu with the pandemic ability of swine flu, according to a new study. Two viruses infecting a single host cell can swap genetic material, or reassort, creating hybrid strains with characteristics of each parent virus.
[Journal] Kawaoka: Hybrid swine-bird flu virus possible, extremely lethal ...: "H5N1 virus has never acquired the ability to transmit among humans, which is why we haven't had a pandemic. The worry is that the pandemic H1N1 virus may provide that nature in the background of this highly pathogenic H5N1 virus," says Kawaoka, a professor of pathobiological sciences at the UW-Madison School of Veterinary Medicine.
[The Speculist] The Speculist: The Avian Flu Threat: If the disease were as vicious as the Influenza Pandemic of 1918, deaths worldwide could reach or exceed 50 million, even if a successful vaccine were developed and distributed.
[Roger's Blog] How about a combination Bird Flu and Swine Flu...probably coming soon: The researchers say surveillance of viral populations is critical to monitor the potential emergence of highly pathogenic viral variants due to reassortment of avian and human influenza viruses. Their results, including identification of the PB2 segment as a key to enhanced virulence, offer information likely to be useful in the event of a pandemic caused by a hybrid avian-human influenza strain.
[WSJ.com: Health Blog] More Deadly Swine Flu? CDC Mixes H1N1, H5N1 Viruses in Tests ...: The scientists want to know whether a combination of the H1N1 virus - highly transmissible, but not terribly deadly - and the H5N1 flu virus could create an easily transmissible, deadly scourge. The H5N1 virus has only sickened 440 people world-wide since 2003 and generally isnt transmitted from one person to another.
[Health News] Human, bird flu virus interaction can create more virulent strains: “H5N1 virus has never acquired the ability to transmit among humans, which is why we haven’t had a pandemic. The worry is that the pandemic H1N1 (swine flu) virus may provide that nature in the background of this highly pathogenic H5N1 virus,”
[Canpazari Blog turk forum] 50. Reassortment between avian H5N1 and human H3N2 influenza ...: Reassortment between avian H5N1 and human H3N2 influenza viruses creates hybrid viruses with substantial virulence, Chengjun Li, Masato Hatta, Chairul A. Nidom, Yukiko Muramoto, Shinji Watanabe, Gabriele Neumann, Yoshihiro Kawaoka<br />Mar 9, 2010;
[Bird Flu Monitor] Bird Flu Monitor: Bird flu death toll reaches 34 | Chen Qi-The ...: This Video Describes How Different Animal Species or Groups are Susceptible or NOT to The AVIAN-FLU Called H5N1 influenza virus. ... How is the swine flu a new virus when it was around in 1976? ... Two viruses infecting a single host cell can swap genetic material, or reassort, creating hybrid strains with characteristics of each parent virus. H5N1 News Summary: March 2010 | Influenza Virus . ...