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[Health Protection Agency] HPA - Health Protection Agency produces swine flu vaccine candidate: This process has been used successfully over many years both in the development of seasonal vaccine candidates and for an H5N1 bird flu vaccine strain. The idea is to make a virus that is recognised by the human body as the 'real swine H1N1 virus' but that is safe and easy to grow up in large quantities in vaccine manufacturing facilities.

[World Pharma News] World Pharma News - US Department of Health and Human Services ...: GSK's H5N1 vaccine, which includes the AS03 adjuvant system, is currently approved in Europe and some Asian countries, GSK is working with US Food and Drug Administration (FDA) and other government authorities with regard to its adjuvant and A (H1N1) candidate vaccine development. Fifteen clinical trials are ongoing to generate additional data for the adjuvant system, including a trial program for a seasonal influenza vaccine.

[Recombinomics Whats New] More H5N1 Receptor Binding Domain Changes: However, the vast majority of clade 2.2 isolates have eliminated both of these sites reducing the number of required receptor binding changes from 3 to 2. However, different clades may use different combinations to change specificties, so the absence of glycosylation at both positions may create additional combinations.

[TeddsAdventure's Posts - VegHaven.org] Bird Flu May Kill Us All - Because WHO Won't Share It's Data with ...: However, this season there have been no sequences released, even though two 2009 isolates, A/Egypt/0001-NAMRU-3/2009 and A/Egypt/0585-NAMRU-3/2009 are listed on the WHO tree. These isolates are related to the vaccine resistant sequences .

[Recombinomics Whats New] WHO Hoarding of H5N1 Sequences Raise Pandemic Concerns: This outbreak involved one of the most extended human to human transmission chains reported to date for H5N1, yet the sequence of the only recovered isolate has been withheld. It is in the phylogenetic tree and is the first reported human case linked to the Uvs Lake strain the Qinghai sub-clade, 2.2.3, and was said to not have receptor binding domain changes, which would also be a first for a clade 2.2 extended human to human transmission chain. 

[Drugs.com - Pharma News] GlaxoSmithKline Update: A (H1N1) Influenza Vaccine Development ...: In clinical studies using the H5N1 influenza strain, an adjuvanted formulation has been shown to stimulate a higher immune response while using a smaller amount of antigen as compared to a formulation without adjuvant. The adjuvant system therefore helps to increase the number of vaccine doses that can be produced.1  In addition, in clinical studies with the H5N1 influenza strain, the adjuvanted vaccine demonstrated the potential to provide protection even if the influenza strain drifts (changes slightly).2,3

[Recombinomics Whats New] Data Supporting Enhanced Human H5N1 Transmission in Egypt: In addition to the epidemiological data, suggesting H5N1 infections are significantly higher than the confirmed cases, is the evidence for a genetic change. Although there is no data supporting reassortment between human and avian flu genes, there is little reason to expect such data since there have been no prior reports, including dozens of H5N1 clusters signaling human to human transmission.

[Centurean2's Weblog] The Real Swine Flu- And The Truth About Vaccines”¦. « Centurean2's ...: The Spanish Flu, which was not Spanish at all, was created in the US through an early bioweapons program and injected into healthy young men (i.e., ’soldiers’) as the first mandatory vaccination in the military during WWI (also known as the “War to End Wars” and the “Great War”). The “Spanish Flu”, which originated in Kansas on US Military bases, killed a minimum of 50 million people worldwide (650,000 Americans).

[Kevin Schofield's Weblog] Kevin Schofield's Weblog: The current bird flu has approximately a 70% human mortality rate -- even in healthy adults -- though experts believe that in mutating to become human-to-human transmissable, it will become less deadly. Last week it was reported that Vietnam is seeing a lower mortality rate, 35%, which is good news in that fewer people are dying, but bad news that it may be the leading indicator that H5N1 is indeed mutating.

[ProjectDisaster] ProjectDisaster » Blog Archive » WHO H1N1 Vaccine Teleconference: unknown for influenza A (H1N1) vaccines. Likewise, the safety profile (including the risk of Guillan Barré

[JALAYBI.COM] JALAYBI.COM » Blog Archive » H5N1 Originates From Alaska in 1997: Ԛ Hultin turned virus samples over to the CDC and the U.S. Army (Jeffery Taubenberger) who then proceeded to weaponize the virus H5N1, baptizing his new doomsday creation with the name â┚¬Ã…“Bird Flu.â┚¬Ã‚ Ԛ This virus that had long been eradicated has now been released once more to kill again, this time possibly billions of human beings across the planet, by combining with the brand new killer H1N1 that has the capability to cross barriers in pigs, birds and humans Ԛ becoming a â┚¬Ã…“Super-Superâ┚¬Ã‚ virus.

[News from The Scientist] Can biotech tackle swine flu? :The Scientist [27th April 2009]: Novavax has two vaccine candidates in clinical trials: One, for H5N1, just completed Phase IIa trials, and a seasonal vaccine candidate is in Phase IIa trials now. According to Andrea Sant, an immunologist at the University of Rochester .

[Bird Flu Monitor] Bird Flu Monitor: Live Avian Flu Virus Placed in Baxter Vaccine ...: In searching signs of antiviral resistance, the team found four bird isolates from Egypt carrying a mutation linked with resistance to the older class of flu drugs, the adamantanes (amantadine and rimantadine). HIV , AVIAN, AND NOW WE'RE GIVEN SWINE FLU”¦.Dismantling the Old .

[virology blog] Why swine flu isn't so scary: The preparedness plans developed against the H5N1 influenza threat dramatically improved overall surveillance (we would probably not have learned so fast about the swine virus were it not for these improved capabilities).  Major advances have been initiated by our government to develop new and improved manufacturing processes and exciting new vaccine and antiviral approaches are also in the pipeline, and they show promise of tipping the balance in favor of humans against a devious virus.  For example, universal influenza vaccines (one long-lasting vaccine against all strains) and broadband antivirals are being developed in our academic laboratories and in innovative small biotech companies.  This work has been primarily funded by the NIH and the CDC and it will pay off by diminishing the future impact of influenza on the health of our citizens and on the economy of our country.  It is prudent to prepare against swine influenza, but equally important to keep a balanced outlook and an awareness of our current capabilities.

[News from The Scientist] Journals speed up flu studies :The Scientist [11th May 2009]: Vaccinations are being developed and reformulated constantly at this time due to the pandemic threat of the H5N1 Influenza virus, and most recently, the swine flu virus. Of the two, the H5N1 is believed to be more deadly.

[virology blog] Swine flu: Questions and answers: Q: It is too early to fully understand the current situation, but I would nevertheless draw your attention to the possibility that the very important pollution level and the high altitude of Mexico City (2,250 meters) can be partly responsible for the severity of swine influenza cases reported in Mexico. Remember that to date, all cases reported elsewhere in the world seem rather benign, or at least non-fatal.

Reflected tags on Technorati: Blog, Hemagglutinin Tag Page, Pandemic Tag Page, Bird Flu Monitor