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[Avian Flu Diary] Widespread resistance to both classes of influenza antivirals (adamantanes and neuraminidase inhibitors) occurs in both pandemic and seasonal viruses, rendering these drugs to be of marginal utility in the treatment modality. Worldwide, virtually all 2009 H1N1 and seasonal H3N2 strains are resistant to the adamantanes (rimantadine and amantadine), and the majority of seasonal H1N1 strains are resistant to oseltamivir, the most widely prescribed neuraminidase inhibitor (NAI).

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[Annals of Pharmacotherapy current issue] Seasonal, Avian, and Novel H1N1 Influenza: Prevention and ...: Seasonal H3N2 influenza resistance to adamantanes has increased since 2000 and may be due to selective drug pressure.64 In January 2006, the CDC did not recommend adamantane use and NA inhibitors were suggested for the treatment and prophylaxis of .

[News Releases, News and Information - The Ohio State University] News Room - The Ohio State University: while another strain that was originally susceptible to adamantanes spread to Indonesia and then independently developed resistance in that country. The Google Earth map offers a vivid visualization of exactly where in the world these resistant lineages originated and where they are spreading.

[Table of Contents : Indian Journal of Pharmacology : 2009 - 41(5)] Frontline defense against the next pandemic: Antivirals for avian ...: The first is a "reassortment" event in which genetic material is exchanged between human and avian virus during co-infection of a human and a pig. The second mechanism is a more gradual process of adaptive mutation, whereby the capability of the virus to bind to human cells increases during subsequent infections of humans.[8] Currently H5N1, is the virus strain of avian influenza in circulation in Asia.[9],[10] From mid December 2003 through early February 2004, poultry outbreaks caused by the H5N1 virus were reported in 8 Asian countries, which include the Republics of Korea and Indonesia, Vietnam, Japan, Thailand, Cambodia, Republic of Indonesia and China and Lao People's Democratic Republic.[8]

[Table of Contents : Indian Journal of Medical Microbiology : 2010 - 28(1)] Emergence of novel influenza A/H1N1 virus as a pandemic agent Ravi ...: In the new millennium, the world has seen the emergence of three novel human respiratory viruses; SARS virus (a novel Corona virus) in 2003, Influenza H5N1 ('Avian flu') in 2004 and in the past six weeks, an international outbreak caused .

[CDC Flu updates] CDC - Seasonal Influenza (Flu) - Q & A: Influenza Antiviral Drug ...: During the 2007-08 influenza season, the CDC influenza laboratory and other influenza laboratories around the world showed a significant increase in the prevalence of resistance to oseltamivir among A (H1N1) viruses. In the U.S, about 13% of H1N1 viruses were found to be resistant to oseltamivir, whereas prior to 2007-08, less than 1% of viruses were resistant.

[Dr. Rath Health Foundation] Swine Flu and Human Influenza -Questions and Answers | The Dr ...: For example, the swine flu that appeared in 1918 was named H1N1, while a later strain of influenza which was found to have changed its hemagglutinin molecules was named H2N1, and an even later influenza was found to have changed both its surface molecules (double antigenic shift), and was named H2N2. These changes are the result of an exchange of genetic materials between flu viruses originating from different sources.

[Eurosurveillance latest updates] Eurosurveillance - View Article: In 21 of the 30 countries, NIRLs had plans to introduce or extend antiviral susceptibility testing for NAIs and/or adamantanes over the next winter seasons using either phenotypic analysis (17 NIRLs in 14 countries for NAIs and 15 NIRLs in 13 countries for adamantanes) and/or genotypic analysis (22 NIRLs in 20 countries for NAIs and 16 NIRLs in 14 countries for adamantanes), while NIRLs in nine countries had no plans to introduce any testing. Taking into account these planned activities, NIRLs in 14 out of the 29 countries with a NAI stockpile would have the capacity to perform the phenotypic analysis, and NIRLs in 20 countries would have the capacity to undertake genotypic analysis to assess NAI resistance.

[Nic-the Habit: Smoking Cessation and Medical News] Swine Flu (North American Influenza) Questions and Answers ...: There are vaccines for pigs to prevent the illness. Four main virus subtypes - H1N1, H1N2, H3N2 and H3N1 - have been isolated in pigs, The swine H1N1 virus is not the same as the human H1N1 virus, so vaccines for the latter won’t protect from the former.  Neither is this virus the classical human influenza virus called seasonal influenza, which causes every year millions of human cases of influenza worldwide but a virus which includes in its characteristics swine, avian and human virus components.

[OwningPink] Swine Flu and Pregnancy | OwningPink: These actions include frequent handwashing, covering coughs, and having ill persons stay home, except to seek medical care, and minimize contact with others in the household who may be ill with swine flu. Additional measures that can limit transmission of a new influenza strain include voluntary home quarantine of members of households with confirmed or probable swine influenza cases, reduction of unnecessary social contacts, and avoidance whenever possible of crowded settings.

[Chen Qi-The World of Micro-Organism HAITI |DENGUE FEVER| H5N1 |UNICEF] H1N1 limits Hajj and Umra for Yemenis | Chen Qi -The World of ...: USAFSAM performs pyrosequencing on 2009 pH1N1 viruses to detectgenetic markers for resistance to neuraminidase inhibitors (oseltamivir) and M2 ion-channel blockers (amantadine and rimantadine). To date, 0% of specimens indicated resistance to oseltamivir, whereas 100% of specimens indicated resistance to adamantanes.

[在海边嬉戏的熊] 轮回: Less virulent H1N1 strains still exist in the wild today, worldwide, causing a small fraction of all influenza-like illness and a large fraction of all seasonal influenza. H1N1 strains caused roughly half of all flu infections in 2006.

[Samny Houes:: 痞客邦PIXNET ::] Influenza A virus subtype H5N1: The hemagglutinin (HA) and neuraminidase (NA) RNA strands specify the structure of proteins that are most medically relevant as targets for antiviral drugs and antibodies. HA and NA are also used as the basis for the naming of the different subtypes of influenza A viruses.

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