Bird Flu Monitor > Toddler to Toddler H5N1 Transmission in Beheira Egypt

[Recombinomics Whats New] The Beheira cluster has the classical gap and there has been no indication that the two toddlers were related. Although it is likely that mild H5N1 has was transmitted human to human, based on the sequence identity between isolates from unrelated cases, the current cluster has the time and space signature associated with human to human transmission.

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[Recombinomics Whats New] Human Transmission in H5N1 Toddler Cluster in Beheira Egypt: The human to human transmission would be further supported by a close similarity between sequences from the neighbors, as was seen in the outbreak of mild H5N1 in the spring of 2007. That outbreak involved older children, but the H5N1 infections were also mild and the number of infections was also likely to have been much higher than the confirmed cases, of which 16/17 survived.

[Flu News Network] Human Transmission in H5N1 Toddler Cluster in Beheira Egypt « Flu ...: The above detail changes the disease onset date of the index case to March 27, indicating symptoms began in Beheira prior to his trip to his grandparents and subsequent hospitalization in Menoufiya (see updated map). The earlier onset date also indicates Tamiflu treatment began more than 48 hours after disease onset, yet the patients is currently in “general good condition”

[Recombinomics Whats New] A Second H5N1 Confirmed Toddler In Beheira Egypt This Week: Consequently, almost all bird flu cases this year involve toddlers. In the prior three years, only 6 of 51 confirmed cases were toddlers. 

[Flu News Network] H5N1 Confirmation Delays in Egypt Raise Concerns « Flu News Network:  Moreover, there is also confusion regarding a 45 day old infant who died March 27 and being hospitalized March 26.  Although sampels were collected from the patient and family, and Tamiflu was given, the test results on this patient have not been announced, even though hospitalization and death were prior to confirmed cases 61-63.

[Recombinomics Whats New] Ninth H5N1 Toddler in Egypt Increases Concerns: Most of the testing in Egypt and elsewhere is limited to patients with known poultry contacts, which would limit the number of hospitalized and suspect patients.

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